Intracerebral hemorrhage (ICH) shares risk factors with arterial ischemic events such as ischemic stroke and myocardial infarction, but it is unclear if ICH is associated with future ischemic events. In a pooled prospective cohort study of nearly 50,000 subjects enrolled from four different U.S population-based studies (ARIC, CHS, REGARDS, and NOMAS), Dr. Murthy and colleagues found that ICH was associated with a 2-fold increased risk of an arterial ischemic event, a 3-fold increased risk of ischemic stroke, and a 2-fold heightened risk of myocardial infarction, independent of vascular risk factors and antithrombotic medication use. This study suggests that ICH may be a novel risk marker for subsequent arterial ischemic disease, highlighting the need for improved secondary cardiovascular prevention strategies after ICH.